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Baldwin was Alabama's fastest-growing county from 2010 to 2020, with 4 of the top 10 fastest-growing cities in the state in recent years. The U.S. federal government designates Baldwin County as the Daphne-Fairhope-Foley, AL Metropolitan Statistical Area. It is the largest county in Alabama by area and is located on the eastern side of Mobile Bay.
Calhoun County is a county in the east central part of the U.S. state of Alabama. As of the 2020 census , the population was 116,441.  Its county seat is Anniston . 
The county seat, Monroeville, is the home of two notable 20th-century authors, Truman Capote and Nelle Harper Lee, who were childhood neighbors. The novelist Mark Childress and journalist Cynthia Tucker are also Monroe County natives. In 1997 the Alabama Legislature designated Monroeville and Monroe County as the "Literary Capital of Alabama".
Cherokee County, Alabama is a county located in the northeastern part of the U.S. state of Alabama. As of the 2020 census , the population was 24,971.  Its county seat is Centre . 
The county was named after Joseph M. Wilcox, a US Army lieutenant who was killed in Alabama during the Creek War. Geography. According to the United States Census Bureau, the county has a total area of 907 square miles (2,350 km 2), of which 888 square miles (2,300 km 2) is land and 19 square miles (49 km 2) (2.1%) is water.
Tuscaloosa County is a county in the northwest-central portion of the U.S. state of Alabama and is the center of commerce, education, industry, health care, and entertainment for the region. The county's population was 227,036 as of the 2020 census . 
According to the United States Census Bureau, the county has a total area of 1,253 square miles (3,250 km 2), of which 1,238 square miles (3,210 km 2) is land and 14 square miles (36 km 2) (or 1.1%) is water. It is the third-largest county in Alabama by land area and the fourth-largest by total area. Major highways
Etowah County is a county located in the northeastern part of the U.S. state of Alabama. As of the 2020 census the population was 103,436. Its county seat is Gadsden. Its name is from a Cherokee word meaning "edible tree". In total area, it is the smallest county in Alabama, but one of the most densely populated.