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Human leukocyte antigen. The human leukocyte antigen ( HLA) system or complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]
HLA is a major histocompatibility complex (MHC) antigen specific to humans. HLA-A is one of three major types of human MHC class I transmembrane proteins. The others are HLA-B and HLA-C. [2] The protein is a heterodimer, and is composed of a heavy α chain and smaller β chain. The α chain is encoded by a variant HLA-A gene, and the β chain ...
The HLA Informatics Group ( HIG) is a research group led by Professor Steven Marsh at the Anthony Nolan Research Institute that develops, runs and maintains the IMGT ( immunogenetics )/HLA ( Human leukocyte antigen) Database and the IPD (immuno polymorphism database). The IMGT/HLA database originated as part of IMGT and was merged with IPD in ...
HLA-NET is a network targeted to the study of Human leukocyte antigen (HLA) from a populational point of view. The network was initiated by COST Action BM0803 [1] in January 2009. Currently HLA-NET activities are being coordinated by a subcommittee of the scientific committee of the European Federation for Immunogenetics .
Histocompatibility. Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC). [1] Each individual expresses many unique HLA proteins on the surface of their cells, which signal to the immune ...
Human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system. Condition. Associated HLA allele (s) Fixed drug eruption. B22. Lichen planus. DR1. DR2. DRw9.
1w0w , 1uxw , 1of2 , 1k5n . Human leukocyte antigen (HLA) B27 (subtypes B*2701-2759) [1] is a class I surface molecule encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing ...
Steven GE Marsh BSc ARCS PhD FRCPath, is a British immunogeneticist and leader in the field of histocompatibility and immunogenetics having published more than 400 scientific papers on the subject. [1] [2] Marsh holds a professorship in the subject at University College London and the deputy directorship of research and leader of the HLA ...