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Adenosine diphosphate (ADP), also known as adenosine pyrophosphate (APP), is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP consists of three important structural components: a sugar backbone attached to adenine and two phosphate groups bonded to the 5 carbon atom of ribose.
Adenosine diphosphate (ADP) receptor inhibitors are a drug class of antiplatelet agents, used in the treatment of acute coronary syndrome (ACS) or in preventive treatment for patients who are in risk of thromboembolism, myocardial infarction or a stroke. These drugs antagonize the P2Y 12 platelet receptors and therefore prevent the binding of ...
ADP-ribose. ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. [ 1 ][ 2 ] It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. [ 3 ][ 4 ] Improper ADP-ribosylation has been implicated in some forms of ...
NCBI. proteins. ADP-ribose diphosphatase ( EC 3.6.1.13) is an enzyme that catalyzes a hydrolysis reaction in which water nucleophilically attacks ADP-ribose to produce AMP and D-ribose 5-phosphate. Enzyme hydrolysis occurs by the breakage of a phosphoanhydride bond and is dependent on Mg 2+ ions that are held in complex by the enzyme.
In enzymology, an ADP-sugar diphosphatase ( EC 3.6.1.21) is an enzyme that catalyzes the chemical reaction. Thus, the two substrates of this enzyme are ADP-sugar and H 2 O, whereas its two products are AMP and alpha-D-aldose 1-phosphate . This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus ...
In enzymology, a glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) is an enzyme that catalyzes the chemical reaction. Thus, the two substrates of this enzyme are ATP and alpha-D- glucose 1-phosphate, whereas its two products are diphosphate and ADP-glucose. This enzyme belongs to the family of transferases, specifically those transferring ...
Adenosine diphosphate ribose (ADPR) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. [1] ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD +) as a cofactor. [1] ADPR binds to and activates the TRPM2 ion channel. [2] ADPR is the most potent agonist of ...
In 1961, the company changed its name to Automatic Data Processing, Inc. (ADP), and began using punched card machines, check printing machines, and mainframe computers. ADP went public in 1961 with 300 clients, 125 employees, and revenues of approximately US$400,000. [3] The company established a subsidiary in the United Kingdom in 1965.