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High-grade serous carcinoma. High-grade serous carcinoma ( HGSC) is a type of tumour that arises from the serous epithelial layer in the abdominopelvic cavity and is mainly found in the ovary. HGSCs make up the majority of ovarian cancer cases [1] and have the lowest survival rates. [2] HGSC is distinct from low-grade serous carcinoma (LGSC ...
In October 2019, the indication for niraparib was expanded to include people with advanced ovarian, fallopian tube, or primary peritoneal cancer treated with three or more prior chemotherapy regimens and whose cancer is associated with homologous recombination deficiency (HRD)-positive status. HRD is defined by either a deleterious or suspected ...
Ovarian cancer is a cancerous tumor of an ovary. [10] It may originate from the ovary itself or more commonly from communicating nearby structures such as fallopian tubes or the inner lining of the abdomen.
HRDetect. HRDetect [1] ( H omologous R ecombination D eficiency D etect) is a whole-genome sequencing (WGS)-based classifier designed to predict BRCA1 and BRCA2 deficiency based on six mutational signatures. Additionally, the classifier is able to identify similarities in mutational profiles of tumors to that of tumors with BRCA1 and BRCA2 ...
Ovarian tumor. Gross pathology of an ovarian carcinoma. Ovarian tumors, or ovarian neoplasms, are tumors found in the ovary. They can be benign or malignant ( ovarian cancer ). They consist of mainly solid tissue, while ovarian cysts contain fluid.
The woman's ten-year risk for ovarian cancer is also increased by 6-12% under these conditions. Statistics for BRCA-related ovarian cancer typically encompass not only cancer of the ovaries themselves, but also peritoneal cancer and the very rare, but somewhat easier to detect, cancer of the fallopian tubes.
Ovarian squamous cell carcinoma (oSCC) or squamous ovarian carcinoma (SOC) is a rare tumor that accounts for 1% of ovarian cancers. [1] Included in the World Health Organization 's classification of ovarian cancer, [2] it mainly affects women above 45 years of age. Survival depends on how advanced the disease is and how different or similar the ...
Ovarian clear-cell carcinoma, or clear-cell carcinoma of the ovary, also called ovarian clear-cell adenocarcinoma, is one of several subtypes of ovarian carcinoma – a subtype of epithelial ovarian cancer, in contrast to non-epithelial cancers. According to research, most ovarian cancers start at the epithelial layer which is the lining of the ...