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High-grade serous carcinoma ( HGSC) is a type of tumour that arises from the serous epithelial layer in the abdominopelvic cavity and is mainly found in the ovary. HGSCs make up the majority of ovarian cancer cases [1] and have the lowest survival rates. [2] HGSC is distinct from low-grade serous carcinoma (LGSC) which arises from ovarian ...
HRDetect. HRDetect [1] ( H omologous R ecombination D eficiency D etect) is a whole-genome sequencing (WGS)-based classifier designed to predict BRCA1 and BRCA2 deficiency based on six mutational signatures. Additionally, the classifier is able to identify similarities in mutational profiles of tumors to that of tumors with BRCA1 and BRCA2 ...
The Pap test does not screen for ovarian cancer. Ovarian cancer is usually only palpable in advanced stages. This high risk group has benefited with earlier detection. Screening is not recommended using CA-125 measurements, HE4 levels, ultrasound, or adnexal palpation in women who are at average risk. Currently there is no national screening ...
In both breast and ovarian screening, areas of tissue that look suspicious are investigated with either more imaging, possibly using a different type of imaging or after a delay, or with biopsies of the suspicious areas. Medication. Birth control pills are associated with substantially lower risk of ovarian cancer in women with BRCA mutations.
BRCA1 is a human tumor suppressor gene [7] [8] (also known as a caretaker gene) and is responsible for repairing DNA. [9] BRCA1 and BRCA2 are unrelated proteins, [10] but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired.
Ovarian tumor. Gross pathology of an ovarian carcinoma. Ovarian tumors, or ovarian neoplasms, are tumors found in the ovary. They can be benign or malignant ( ovarian cancer ). They consist of mainly solid tissue, while ovarian cysts contain fluid.
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