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Aging's effect on cancer is complicated by factors such as DNA damage and inflammation promoting it and factors such as vascular aging and endocrine changes inhibiting it. Parkinson's. Parkinson's disease, or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
Aging of the brain is a process of transformation of the brain in older age, including changes all individuals experience and those of illness (including unrecognised illness). Usually this refers to humans. Since life extension is only pertinent if accompanied by health span extension, and, more importantly, by preserving brain health and ...
Epigenetic clock theory of aging. In 2010, a new unifying model of aging and the development of complex diseases was proposed, incorporating classical aging theories and epigenetics. Horvath and Raj extended this theory, proposing an epigenetic clock theory of aging with the following tenets:
Braak staging. A. Schematic initial progression of Lewy body deposits in the first stages of Parkinson's Disease, as proposed by Braak and colleagues. B. Localization of the area of significant brain volume reduction in initial PD compared with a group of participants without the disease in a neuroimaging study which concluded that brain stem ...
The antagonistic pleiotropy hypothesis was first proposed in a 1952 paper on the evolutionary theory of ageing by Peter Medawar and developed further in a landmark paper by George C. Williams in 1957. [1] Their original hypotheses have since spurred a huge and fruitful literature on the evolutionary explanation for senescence. [2]
The history of Parkinson's disease expands from 1817, when British apothecary James Parkinson published An Essay on the Shaking Palsy, to modern times. Before Parkinson's descriptions, others had already described features of the disease that would bear his name, while the 20th century greatly improved knowledge of the disease and its ...
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