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The membrane (M) protein (previously called E1, sometimes also matrix protein [2]) is an integral membrane protein that is the most abundant of the four major structural proteins found in coronaviruses. [3] [4] [5] The M protein organizes the assembly of coronavirus virions through protein-protein interactions with other M protein molecules as ...
The COVID-19 vaccination campaign in the United States is an ongoing mass immunization campaign for the COVID-19 pandemic in the United States. The Food and Drug Administration (FDA) first granted emergency use authorization to the Pfizer–BioNTech vaccine on December 10, 2020, [7] and mass vaccinations began four days later.
Variants of severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2) are viruses that, while similar to the original, have genetic changes that are of enough significance to lead virologists to label them separately. SARS-CoV-2 is the virus that causes coronavirus disease 2019 (COVID-19).
The Medigen COVID-19 vaccine is the first domestic COVID-19 vaccine that was given EUA approval by the Taiwanese government and the first in the world. Despite the vaccine has proven to be safe through its Phase 2 clinical trial, the approval was still considered a controversial political move due to the lack of efficacy data and Phase 3 ...
The nucleocapsid (N) protein is a protein that packages the positive-sense RNA genome of coronaviruses to form ribonucleoprotein structures enclosed within the viral capsid. [2] [3] The N protein is the most highly expressed of the four major coronavirus structural proteins. [2] In addition to its interactions with RNA, N forms protein-protein ...
SARS-related coronavirus is a member of the genus Betacoronavirus (group 2) and monotypic of the subgenus Sarbecovirus (subgroup B). [13] Sarbecoviruses, unlike embecoviruses or alphacoronaviruses, have only one papain-like proteinase (PLpro) instead of two in the open reading frame ORF1ab. [14] SARSr-CoV was determined to be an early split-off ...
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a coronavirus related to Rhinolophus bat coronavirus HKU2. It is transmitted through the feces of horseshoe bats to pigs. Piglets less than 5 days old die with a probability of up to 90%. The first outbreak appeared in 2017, where it caused the death of more than 24,000 piglets on 4 farms.
Human coronavirus HKU1 ( HCoV-HKU1) is a species of coronavirus in humans and animals. It causes an upper respiratory disease with symptoms of the common cold, but can advance to pneumonia and bronchiolitis. [1] It was first discovered in January 2004 from one man in Hong Kong. [2] Subsequent research revealed it has global distribution and ...