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Faecal calprotectin. Faecal calprotectin ( or fecal calprotectin) is a biochemical measurement of the protein calprotectin in the stool. Elevated faecal calprotectin indicates the migration of neutrophils to the intestinal mucosa, which occurs during intestinal inflammation, including inflammation caused by inflammatory bowel disease.
Calprotectin is a complex of the mammalian proteins S100A8 and S100A9. [1] [2] Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosis antigen, L1, 60BB antigen, and 27E10 antigen. [2] [3] The proteins exist as homodimers but preferentially exist as S100A8/A9 heterodimers or heterotetramers (calprotectin) with ...
Fecal calprotectin, a marker of colon inflammation, may be elevated in individuals with SCAD. Fecal calprotectin may assist in distinguishing SCAD from irritable bowel syndrome. Imaging tests, including CT abdomen, may show inflammation or thickening of the distal colon, with associated diverticulosis.
Ulcerative colitis ( UC) is one of the two types of inflammatory bowel disease (IBD), with the other type being Crohn's disease. [1] It is a long-term condition that results in inflammation and ulcers of the colon and rectum. [1] [7] The primary symptoms of active disease are abdominal pain and diarrhea mixed with blood ( hematochezia ). [1]
S100A8. S100 calcium-binding protein A8 ( S100A8) is a protein that in humans is encoded by the S100A8 gene. [5] It is also known as calgranulin A. The proteins S100A8 and S100A9 form a heterodimer called calprotectin . The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.
Checkpoint inhibitor induced colitis is an inflammatory condition affecting the colon ( colitis ), which is caused by cancer immunotherapy ( checkpoint inhibitor therapy ). Symptoms typically consist of diarrhea, abdominal pain and rectal bleeding. Less commonly, nausea and vomiting may occur, which may suggest the present of gastroenteritis.
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