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Parkinson's disease (PD) is a complicated neurodegenerative disease that progresses over time and is marked by bradykinesia, tremor, and stiffness.As the condition worsens, some patients may also experience postural instability. [1]
In 2010, a new unifying model of aging and the development of complex diseases was proposed, incorporating classical aging theories and epigenetics. [ 20 ] [ 21 ] Horvath and Raj [ 22 ] extended this theory, proposing an epigenetic clock theory of aging with the following tenets:
The metabolic stability theory of aging suggests it is the cells ability to maintain stable concentration of ROS which is the primary determinant of lifespan. [37] This theory criticizes the free radical theory because it ignores that ROS are specific signalling molecules which are necessary for maintaining normal cell functions. [37]
It is also more frequent in people with Parkinson's disease and chronic obstructive pulmonary disease. People with Parkinson's disease have a higher risk of broken bones. This is related to poor balance and poor bone density. [73] In Parkinson's disease there may be a link between the loss of dopaminergic neurons and altered calcium metabolism ...
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body. The symptoms usually emerge slowly, and, as the disease progresses, non-motor symptoms become more common.
Locus coeruleus and its influence pathways. The locus coeruleus (/ s ɪ ˈ r uː l i ə s /) (LC), also spelled locus caeruleus or locus ceruleus, [1] is a nucleus in the pons of the brainstem involved with physiological responses to stress and panic. [2]
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