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The β C subunit is able to form activin heterodimers with β A or β B subunits but is unable to dimerize with inhibin α. Function Activin. Activin is produced in the gonads, pituitary gland, placenta, and other organs: In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization.
InterPro. The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions.
An Activin receptor is a receptor which binds activin. These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain. [1] [2] [3] Types include: Activin type 1 receptors. Activin type 2 receptors.
ACVR1. Activin A receptor, type I ( ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 ( a ctivin receptor- l ike k inase-2). [5] ACVR1 has been linked to the 2q23-24 region of the genome. [6] This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and ...
HPG regulation in males, with the inhibin/activin system playing a similar role on GnRH-producing cells. The hypothalamus is located in the brain and secretes GnRH. GnRH travels down the anterior portion of the pituitary via the hypophyseal portal system and binds to receptors on the secretory cells of the adenohypophysis.
The brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making ...
The Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones include activin, anti-Müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell ...
ACVR1B. Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene. [5] [6] ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B.
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