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Aribit (Aripiprazole) tablets. Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. [8] It is primarily used in the treatment of schizophrenia and bipolar disorder; [8] other uses include as an add-on treatment in major depressive disorder and obsessive–compulsive disorder (OCD), tic disorders, and irritability associated with autism. [8]
Epoxygenases are a set of membrane-bound, heme -containing cytochrome P450 (CYP450 or just CYP) enzymes that metabolize polyunsaturated fatty acids (PUFAs) to epoxide products that have a range of biological activities. [1] The most thoroughly-studied substrate of the CYP epoxygenases is the PUFA arachidonic acid (AA).
Bristol-Myers Squibb Company. The Bristol-Myers Squibb Company, doing business as Bristol Myers Squibb (BMS), is an American multinational pharmaceutical company. Headquartered in Princeton, New Jersey, [2] BMS is one of the world's largest pharmaceutical companies and consistently ranks on the Fortune 500 list of the largest U.S. corporations.
The U.S. health regulator on Wednesday approved the expanded use of Bristol Myers Squibb's cancer cell therapy Breyanzi for the treatment of adults with a type of blood cancer called follicular ...
Cytochrome P450. Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases. [1] However, they are not omnipresent; for example, they have not been found in Escherichia coli. [2] In mammals, these enzymes oxidize steroids, fatty acids, xenobiotics, and ...
December 11, 2023 at 6:03 PM. By Michael Erman. (Reuters) -Bristol Myers Squibb said on Monday it will pay $800 million up front and up to $8.4 billion to Sichuan Biokin Pharmaceutical to develop ...
Cytochrome P450 (individual enzymes) In biochemistry, cytochrome P450 enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, and archaea, as well as in viruses. [1] As of 2018, more than 300,000 distinct CYP proteins are known. [2][3]
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