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  2. Pathophysiology of Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Neuronal_Death_in_Parkinson...

    The first major proposed cause of neuronal death in Parkinson's disease is the bundling, or oligomerization, of proteins. The protein alpha-synuclein has increased presence in the brains of Parkinson's Disease patients and, as α-synuclein is insoluble, it aggregates to form Lewy bodies (shown to left) in neurons.

  3. Cell-based therapies for Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Cell-based_Therapies_for...

    The first cell-based therapy investigated for Parkinson's disease utilized the adrenal medulla. The adrenal medulla is the innermost part of the adrenal gland and contains neural crest derived chromaffin cells which secrete norepinephrine, epinephrine and to a far lesser extent dopamine into the blood. Autotransplantation of adrenal medullary ...

  4. Health effects of coffee - Wikipedia

    en.wikipedia.org/wiki/Health_effects_of_coffee

    Mental health. The UK National Health Service advises that avoiding coffee may reduce anxiety. [32] In chronic psychiatric patients, caffeine, the major active ingredient in coffee, is associated with anxiety. [33] [34] At high doses, typically greater than 300 mg, caffeine can both cause and worsen anxiety. [35]

  5. Dietary management of Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Dietary_management_of...

    Dietary management of Parkinson's disease. Parkinson's disease is the 2nd most prevalent neurological disorder within the United States and Europe, affecting around 1% of the population over the age of 60. [1] While the link connecting the onset of Parkinson's disease to environmental factors is known, the link between dietary patterns and the ...

  6. Lesch–Nyhan syndrome - Wikipedia

    en.wikipedia.org/wiki/Lesch–Nyhan_syndrome

    A less severe, related disease, partial HPRT deficiency, is known as Kelley–Seegmiller syndrome (Lesch–Nyhan syndrome involves total HPRT deficiency). Symptoms generally involve less neurological involvement but the disease still causes gout and kidney stones. Genetics LNS is inherited in an X-linked recessive fashion.

  7. Signs and symptoms of Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Signs_and_symptoms_of...

    Parkinson's disease patient showing a typical flexed walking posture in advanced stage. Signs and symptoms of Parkinson's disease are varied. Parkinson's disease affects movement, producing motor symptoms. [1] Non-motor symptoms, which include dysautonomia, cognitive and neurobehavioral problems, and sensory and sleep difficulties, are also ...

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