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BLAST, which The New York Times called the Google of biological research, [3] is one of the most widely used bioinformatics programs for sequence searching. [4] It addresses a fundamental problem in bioinformatics research. The heuristic algorithm it uses is much faster than other approaches, such as calculating an optimal alignment.
Sequence alignment. In bioinformatics, a sequence alignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences. [1] [2] Aligned sequences of nucleotide or amino acid residues are typically ...
Distributed with the latest version of BLAST, this wrapper facilitates parallelization of the algorithm on modern hybrid architectures with many nodes and many cores within each node. Protein: Burdyshaw CE, Sawyer S, Horton MD, Brook RG, Rekapalli B: 2017 CS-BLAST: Sequence-context specific BLAST, more sensitive than BLAST, FASTA, and SSEARCH.
FMA. 83524. Anatomical terms of microanatomy. [ edit on Wikidata] The myeloblast is a unipotent stem cell which differentiates into the effectors of the granulocyte series. It is found in the bone marrow. Stimulation of myeloblasts by G-CSF and other cytokines triggers maturation, differentiation, proliferation and cell survival. [1]
A nuclear explosion is an explosion that occurs as a result of the rapid release of energy from a high-speed nuclear reaction.The driving reaction may be nuclear fission or nuclear fusion or a multi-stage cascading combination of the two, though to date all fusion-based weapons have used a fission device to initiate fusion, and a pure fusion weapon remains a hypothetical device.
Positive and zero values have been highlighted. In bioinformatics, the BLOSUM ( BLO cks SU bstitution M atrix) matrix is a substitution matrix used for sequence alignment of proteins. BLOSUM matrices are used to score alignments between evolutionarily divergent protein sequences. They are based on local alignments.
A BLAST variant called MegaBLAST indexes 4 databases to speed up alignments. BLAT can extend on multiple perfect and near-perfect matches (default is 2 perfect matches of length 11 for nucleotide searches and 3 perfect matches of length 4 for protein searches), while BLAST extends only when one or two matches occur close together.
Website. fasta .bioch .virginia .edu. www .ebi .ac .uk /Tools /sss /fasta. FASTA is a DNA and protein sequence alignment software package first described by David J. Lipman and William R. Pearson in 1985. [1] Its legacy is the FASTA format which is now ubiquitous in bioinformatics .