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Activin is a dimer composed of two identical or very similar beta subunits. Inhibin is also a dimer wherein the first component is a beta subunit similar or identical to the beta subunit in activin. However, in contrast to activin, the second component of the inhibin dimer is a more distantly-related alpha subunit.
InterPro. The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions.
INHBA is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects. Function [ edit ] The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor.
ACVR1. Activin A receptor, type I ( ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 ( a ctivin receptor- l ike k inase-2). [5] ACVR1 has been linked to the 2q23-24 region of the genome. [6] This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and ...
The Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones include activin, anti-Müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell ...
11481 Ensembl ENSG00000114739 ENSMUSG00000061393 UniProt Q13705 P27040 RefSeq (mRNA) NM_001106 NM_007397 NM_001313757 RefSeq (protein) NP_001097 NP_001300686 NP_031423 Location (UCSC) Chr 3: 38.45 – 38.49 Mb Chr 9: 119.23 – 119.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an ...
Alpha-actinin-2. Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. [5] This gene encodes an alpha-actinin isoform that is expressed in both skeletal and cardiac muscles and functions to anchor myofibrillar actin thin filaments and titin to Z-discs .
The heart is a muscular organ situated in the mediastinum.It consists of four chambers, four valves, two main arteries (the coronary arteries), and the conduction system. The left and right sides of the heart have different functions: the right side receives de-oxygenated blood through the superior and inferior venae cavae and pumps blood to the lungs through the pulmonary artery, and the left ...