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17216 Ensembl ENSG00000073111 ENSMUSG00000002870 UniProt P49736 P97310 RefSeq (mRNA) NM_004526 NM_008564 RefSeq (protein) NP_004517 NP_032590 Location (UCSC) Chr 3: 127.6 – 127.62 Mb Chr 6: 88.86 – 88.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene. Function The protein encoded by ...
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The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. [1][2] As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest ...
The catalytic core of the helicase is composed of six minichromosome maintenance (Mcm2-7) proteins, forming a hexameric ring. Away from DNA, the Mcm2-7 proteins form a single heterohexamer and are loaded in an inactive form at origins of DNA replication as a head-to-head double hexamers around double-stranded DNA.
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