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D09999. Tramadol/paracetamol, also known as tramadol/acetaminophen and sold under the brand name Ultracet among others, is a fixed-dose combination medication used for the treatment of moderate to severe pain. [3] [4] It contains tramadol, as the hydrochloride, an analgesic; and paracetamol an analgesic. [3] [4] It is taken by mouth.
Monoamine oxidase inhibitor. Monoamine oxidase inhibitors ( MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants, especially for treatment-resistant depression and atypical depression. [1]
Serotonin–norepinephrine reuptake inhibitors ( SNRIs) are a class of antidepressant medications used to treat major depressive disorder (MDD), anxiety disorders, social phobia, chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms. Off-label uses include treatments for attention-deficit hyperactivity disorder (ADHD ...
Tramadol. Tramadol, sold under the brand name Ultram among others, [1] is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderately severe pain. [3] [13] When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. [3]
Naloxegol. Naloxegol ( INN; PEGylated naloxol; [3] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid -induced constipation. [4] It was approved in 2014 in adult patients with chronic, non-cancer pain. [5]
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Desmetramadol ( INN ), also known as O-desmethyltramadol ( O-DSMT ), is an opioid analgesic and the main active metabolite of tramadol. [2] Tramadol is demethylated by the liver enzyme CYP2D6 [3] to desmetramadol in the same way as codeine, and so similarly to the variation in effects seen with codeine, individuals who have a less active form ...
Sibutramine should not be taken within two weeks of stopping or starting an MAOI. Taking both sibutramine and certain medications used in the treatment of migraines—such as ergolines and triptans—as well as opioids, may also increase the risk for serotonin syndrome, as may the use of more than one serotonin reuptake inhibitor at the same time.