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17216 Ensembl ENSG00000073111 ENSMUSG00000002870 UniProt P49736 P97310 RefSeq (mRNA) NM_004526 NM_008564 RefSeq (protein) NP_004517 NP_032590 Location (UCSC) Chr 3: 127.6 – 127.62 Mb Chr 6: 88.86 – 88.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene. Function The protein encoded by ...
The minichromosome maintenance protein complex ( MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. [1] [2] As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest ...
The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and ...
The catalytic core of the helicase is composed of six minichromosome maintenance (Mcm2-7) proteins, forming a hexameric ring. Away from DNA, the Mcm2-7 proteins form a single heterohexamer and are loaded in an inactive form at origins of DNA replication as a head-to-head double hexamers around double-stranded DNA.
Function. The MCM complex consisting of MCM6 (this protein) and MCM2, 4 and 7 possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.
ATR phosphorylates downstream replication factors, such as RPA2 and MCM2 or through modulation of Rb or p53. Ataxia telangiectasia mutated (ATM) activates after a larger amount of DSBs is detected at later stages of DNA re-replication. While ATM plays a role in cell cycle arrest, apoptosis, and senescence, it is also suspected to play a role in ...
Control of chromosome duplication. Overview of chromosome duplication in the cell cycle. In cell biology, eukaryotes possess a regulatory system that ensures that DNA replication occurs only once per cell cycle . A key feature of the DNA replication mechanism in eukaryotes is that it is designed to replicate relatively large genomes rapidly and ...
A pre-replication complex ( pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of the genome ensures that each daughter cell will carry the same genetic information as the parent cell.