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Minichromosome maintenance. Pfam maps to the core ATP binding domain. The minichromosome maintenance protein complex ( MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. [1] [2] As a critical protein for cell division, MCM is also the target of ...
17216 Ensembl ENSG00000073111 ENSMUSG00000002870 UniProt P49736 P97310 RefSeq (mRNA) NM_004526 NM_008564 RefSeq (protein) NP_004517 NP_032590 Location (UCSC) Chr 3: 127.6 – 127.62 Mb Chr 6: 88.86 – 88.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene. Function The protein encoded by ...
Electronic warfare. & decoys. see text. Armament. six M2HB .50 cal. machine guns, four M240B 7.62mm machine guns, two Mk 19 grenade launchers. USS Defender (MCM-2) was an Avenger -class mine countermeasures ship in the service of the United States Navy. She entered service in September 1989 and was decommissioned in October 2014.
The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and ...
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The catalytic core of the helicase is composed of six minichromosome maintenance (Mcm2-7) proteins, forming a hexameric ring. Away from DNA, the Mcm2-7 proteins form a single heterohexamer and are loaded in an inactive form at origins of DNA replication as a head-to-head double hexamers around double-stranded DNA.
Mathematical Contest in Modeling. The International Mathematical Contest in Modeling ( MCM) is a multi-day mathematical modelling competition held annually in USA, during the first or second weekend in February, since 1985 by COMAP and sponsored by SIAM and INFORMS. It is distinguished from other major mathematical competitions such as the ...