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Respiratory syncytial virus vaccine. A respiratory syncytial virus vaccine, or RSV vaccine, is a vaccine that protects against respiratory syncytial virus. [12] RSV affects an estimated 64 million people and causes 160,000 deaths worldwide each year. [15] The RSV vaccines Arexvy ( GSK ), [3] Abrysvo ( Pfizer ), [9] and Mresvia ( Moderna) [16 ...
Graphic from the World Health Organization describing the main ingredients typically in vaccines. A vaccine dose contains many ingredients (stabilizers, adjuvants, residual inactivating ingredients, residual cell culture materials, residual antibiotics and preservatives) very little of which is the active ingredient, the immunogen. A single ...
Respiratory syncytial virus ( RSV ), [a] also called human respiratory syncytial virus ( hRSV) and human orthopneumovirus, is a contagious virus that causes infections of the respiratory tract. It is a negative-sense, single-stranded RNA virus. [2] Its name is derived from the large cells known as syncytia that form when infected cells fuse.
Early symptoms of RSV in children can include a runny nose, reduced appetite and a cough, which may progress to wheezing. Infants less than 6 months old will almost always show symptoms that can ...
InterPro. Respiratory syncytial virus G protein is a glycoprotein produced by respiratory syncytial virus. [1] [2] [3] Some features of the G protein suggest it could be important to respiratory syncytial virus vaccine or antiviral drug target design. [4] [5]
The excess of boron trichloride was quenched in a mixture of potassium carbonate and methanol. A benzyl-free intermediate was obtained. The isomers were then separated via reversed-phase HPLC. The optically pure compound and intermediate a are reacted with trimethyl phosphate and methylimidazole to obtain a diastereomer mixture of remdesivir.
Palivizumab is a humanized monoclonal antibody (IgG) directed against an epitope in the A antigenic site of the F protein of RSV. In two phase III clinical trials in the pediatric population, palivizumab reduced the risk of hospitalization due to RSV infection by 55% and 45%. [5]
Nirsevimab. Nirsevimab, sold under the brand name Beyfortus, is a human recombinant monoclonal antibody with activity against respiratory syncytial virus (RSV). [10] [11] It is a respiratory syncytial virus (RSV) F protein‑directed fusion inhibitor [6] that is designed to bind to the fusion protein on the surface of the RSV virus. [12] [13]