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An "abnormal" QTc in males is a QTc above 450 ms; and, in females, above 470 ms. [17] If there is not a very high or low heart rate, the upper limits of QT can roughly be estimated by taking QT = QTc at a heart rate of 60 beats per minute (bpm), and subtracting 0.02 s from QT for every 10 bpm increase in heart rate.
Deaths. ≈3,500 a year (U.S.) [6] Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
Drug-induced QT prolongation. QT prolongation is a measure of delayed ventricular repolarisation, which means the heart muscle takes longer than normal to recharge between beats. It is an electrical disturbance which can be seen on an electrocardiogram (ECG). Excessive QT prolongation can trigger tachycardias such as torsades de pointes (TdP).
Quantum tunnelling composites (QTCs) are composite materials of metals and non- conducting elastomeric binder, used as pressure sensors. They use quantum tunnelling: without pressure, the conductive elements are too far apart to conduct electricity; when pressure is applied, they move closer and electrons can tunnel through the insulator.
The cardiac features of JLNS can be diagnosed by measuring the QT interval corrected for heart rate (QTc) on a 12-lead electrocardiogram (ECG). The QTc is less than 450 ms in 95% of normal males, and less than 460 ms in 95% of normal females. In those with Jervell and Lange-Nielsen syndrome the QTc is typically greater than 500 ms. [8]
If the QTc is greater than 440 msec (or 500 msec in patients with ventricular conduction abnormalities), dofetilide is contraindicated. If heart rate is less than 60 bpm, the uncorrected QT interval should be used. After each subsequent dose of dofetilide, QTc should be determined and dosing should be adjusted.
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Quote-to-cash (or QTC or Q2C) is an information technology term for the integration and automated management of end-to-end business processes on the sell side. It includes the following aspects of the sales process: Product (or Service) Configuration. Pricing. Quote creation for a prospect or customer or channel partner, and its negotiation.
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