Why rent a luxury hotel room when you can step it up a notch and have a villa instead? Many people don't consider villas by sheer reason that the thought doesn't occur to them, or if it does it's intimidating because people aren't sure how it works. It's really not that complicated, and the benefits of having your own luxury home (as opposed to just a suite in a hotel) at your disposal for the duration of your vacation are amazing.
As far as which villas you might want to consider take a look at the 10 on this slide show, which are complete with villa renting tips like how to consider whether or not you'll need to rent a car and how to choose the best season. Apparently Croatia is becoming one of the hottest villa-vacation hot spots in Europe, and Meikloeur Castle in Scotland is one of the priciest renting for $37,200 per week (but for that you get your own 18 hole golf course).
